X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.

نویسندگان

  • C C Tsai
  • S C Jain
  • H M Sobell
چکیده

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 72 2  شماره 

صفحات  -

تاریخ انتشار 1975